Autophagy inhibitors suppress environmental particulate matter-induced airway inflammation.
Toxicol Lett
; 280: 206-212, 2017 Oct 05.
Article
in En
| MEDLINE
| ID: mdl-28867211
ABSTRACT
Particulate matter (PM) is a significant risk factor for airway injury. We have recently demonstrated a pivotal role of autophagy in mediating PM-induced airway injury. In the present study, we examined the possible effects of autophagy inhibitors spautin-1 and 3-Methyladenine (3-MA) in protection of PM-induced inflammatory responses. We observed that PM triggered autophagy in human bronchial epithelial (HBE) cells and in mouse airways. Spautin-1 or 3-MA inhibited PM-induced expression of inflammatory cytokines in HBE cells, and decreased the neutrophil influx and proinflammatory cytokines induced by PM in vivo. We further illustrated that autophagy inhibitors suppressed the inflammation responses via inhibition of the nuclear factor-кB (NF-кB) pathway. Thus, this study shows a paradigm that autophagy inhibitors effectively decrease the PM-induced airway inflammation via suppressing the NF-кB pathway, which may provide novel preventive and/or protective approaches for PM-related airway injury.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinazolines
/
Autophagy
/
Benzylamines
/
Adenine
/
Environmental Pollutants
/
Particulate Matter
Type of study:
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Toxicol Lett
Year:
2017
Document type:
Article
Affiliation country:
China