A rapid IL-17 response to Cryptosporidium parvum in the bovine intestine.
Vet Immunol Immunopathol
; 191: 1-4, 2017 Sep.
Article
in En
| MEDLINE
| ID: mdl-28895860
ABSTRACT
Cryptosporidium parvum causes diarrhoea, due to villi damage, in livestock and humans globally. Immunity develops after repeated infections but initial infections can be severe, highlighting the importance of early infection dynamics. We have modelled early C. parvum infection in bovine jejunum biopsies. IL-17A accumulated over time peaking at 9h post-infection, with no effect of infection on IL-1ß; antibiotics positively influenced IL-17A as higher levels were found in cultures with antibiotics. Infection of primary fibroblasts resulted in lower plaque formation when fibroblasts were primed with IL-17A. Our results indicate a role for IL-17A in reducing C. parvum-dependent host cell damage.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cattle Diseases
/
Cryptosporidium parvum
/
Interleukin-17
/
Cryptosporidiosis
/
Intestines
Limits:
Animals
Language:
En
Journal:
Vet Immunol Immunopathol
Year:
2017
Document type:
Article
Affiliation country:
Reino Unido
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS