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No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8+ TILs.
Bailis, Will; Shyer, Justin A; Chiorazzi, Michael; Flavell, Richard A.
Affiliation
  • Bailis W; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Shyer JA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Chiorazzi M; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Flavell RA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: richard.flavell@yale.edu.
Cancer Cell ; 32(3): 280-281, 2017 09 11.
Article in En | MEDLINE | ID: mdl-28898693
ABSTRACT
The tumor microenvironment presents metabolic constraints to immunosurveiling cells. In this issue of Cancer Cell, Zhang et al. demonstrate that CD8+ TILs reprogram under hypoxic and hypoglycemic conditions, regaining effector function by engaging fatty acid catabolism, which is promoted by fenofibrate and synergistic with immune checkpoint blockade therapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocytes, Tumor-Infiltrating / Glucose Limits: Humans Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2017 Document type: Article Affiliation country: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocytes, Tumor-Infiltrating / Glucose Limits: Humans Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2017 Document type: Article Affiliation country: Estados Unidos