Platelet factor 4 increases bone marrow B cell development and differentiation.
Immunol Res
; 65(5): 1089-1094, 2017 10.
Article
in En
| MEDLINE
| ID: mdl-28914425
ABSTRACT
Platelet factor 4 (PF4) is a megakaryocyte-/platelet-derived chemokine with diverse functions as a regulator of vascular and immune biology. PF4 has a central role in vessel injury responses, innate immune cell responses, and T-helper cell differentiation. We have now discovered that PF4 has a direct role in B cell differentiation in the bone marrow. Mice lacking PF4 (PF4-/- mice) had fewer developing B cells in the bone marrow beginning after the pre-pro-B cell stage of differentiation. In vitro, PF4 increased the differentiation of hematopoietic progenitors to B cell lineage cells, indicating that PF4 has a direct effect on B cell differentiation. STAT5 activation is essential in early B cell development and PF4 increased the phosphorylation of STAT5. Taken together, these data demonstrate that PF4 has an important role in increasing B cell differentiation in the bone marrow environment.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Platelet Factor 4
/
Bone Marrow Cells
/
B-Lymphocytes
Limits:
Animals
Language:
En
Journal:
Immunol Res
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2017
Document type:
Article
Affiliation country:
Estados Unidos