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(Re-)programming of subtype specific cardiomyocytes.
Hausburg, Frauke; Jung, Julia Jeannine; Hoch, Matti; Wolfien, Markus; Yavari, Arash; Rimmbach, Christian; David, Robert.
Affiliation
  • Hausburg F; Reference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, Rostock University Medical Center, Schillingallee 69, 18057 Rostock, Germany; Department Life, Light and Matter of the Interdisciplinary Faculty at Rostock University, Albert-Einstein-Straße 25, 1805
  • Jung JJ; Reference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, Rostock University Medical Center, Schillingallee 69, 18057 Rostock, Germany; Department Life, Light and Matter of the Interdisciplinary Faculty at Rostock University, Albert-Einstein-Straße 25, 1805
  • Hoch M; Department of Systems Biology and Bioinformatics, University of Rostock, Ulmenstraße 69, 18057 Rostock, Germany.
  • Wolfien M; Department of Systems Biology and Bioinformatics, University of Rostock, Ulmenstraße 69, 18057 Rostock, Germany.
  • Yavari A; Experimental Therapeutics, Radcliffe Department of Medicine, University of Oxford, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, UK; The Wellcome Trust Centre for Human Genetics, Oxford, UK.
  • Rimmbach C; Reference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, Rostock University Medical Center, Schillingallee 69, 18057 Rostock, Germany; Department Life, Light and Matter of the Interdisciplinary Faculty at Rostock University, Albert-Einstein-Straße 25, 1805
  • David R; Reference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, Rostock University Medical Center, Schillingallee 69, 18057 Rostock, Germany; Department Life, Light and Matter of the Interdisciplinary Faculty at Rostock University, Albert-Einstein-Straße 25, 1805
Adv Drug Deliv Rev ; 120: 142-167, 2017 10 01.
Article in En | MEDLINE | ID: mdl-28916499
Adult cardiomyocytes (CMs) possess a highly restricted intrinsic regenerative potential - a major barrier to the effective treatment of a range of chronic degenerative cardiac disorders characterized by cellular loss and/or irreversible dysfunction and which underlies the majority of deaths in developed countries. Both stem cell programming and direct cell reprogramming hold promise as novel, potentially curative approaches to address this therapeutic challenge. The advent of induced pluripotent stem cells (iPSCs) has introduced a second pluripotent stem cell source besides embryonic stem cells (ESCs), enabling even autologous cardiomyocyte production. In addition, the recent achievement of directly reprogramming somatic cells into cardiomyocytes is likely to become of great importance. In either case, different clinical scenarios will require the generation of highly pure, specific cardiac cellular-subtypes. In this review, we discuss these themes as related to the cardiovascular stem cell and programming field, including a focus on the emergent topic of pacemaker cell generation for the development of biological pacemakers and in vitro drug testing.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocytes, Cardiac / Cellular Reprogramming Limits: Animals / Humans Language: En Journal: Adv Drug Deliv Rev Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2017 Document type: Article Country of publication: Países Bajos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocytes, Cardiac / Cellular Reprogramming Limits: Animals / Humans Language: En Journal: Adv Drug Deliv Rev Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2017 Document type: Article Country of publication: Países Bajos