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Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins.
Rowe, Cliff; Shaeri, Mohsen; Large, Emma; Cornforth, Terri; Robinson, Angela; Kostrzewski, Tomasz; Sison-Young, Rowena; Goldring, Christopher; Park, Kevin; Hughes, David.
Affiliation
  • Rowe C; CN Bio Innovations Limited, BioPark, Broadwater Road, Welwyn Garden City AL7 3AX, UK.
  • Shaeri M; CN Bio Innovations Limited, BioPark, Broadwater Road, Welwyn Garden City AL7 3AX, UK.
  • Large E; CN Bio Innovations Limited, BioPark, Broadwater Road, Welwyn Garden City AL7 3AX, UK.
  • Cornforth T; CN Bio Innovations Limited, BioPark, Broadwater Road, Welwyn Garden City AL7 3AX, UK.
  • Robinson A; CN Bio Innovations Limited, BioPark, Broadwater Road, Welwyn Garden City AL7 3AX, UK.
  • Kostrzewski T; CN Bio Innovations Limited, BioPark, Broadwater Road, Welwyn Garden City AL7 3AX, UK.
  • Sison-Young R; MRC Centre for Drug Safety Science, University of Liverpool, Ashton Street, Liverpool L69 3GE, UK.
  • Goldring C; MRC Centre for Drug Safety Science, University of Liverpool, Ashton Street, Liverpool L69 3GE, UK.
  • Park K; MRC Centre for Drug Safety Science, University of Liverpool, Ashton Street, Liverpool L69 3GE, UK.
  • Hughes D; CN Bio Innovations Limited, BioPark, Broadwater Road, Welwyn Garden City AL7 3AX, UK. Electronic address: david.hughes@cn-bio.com.
Toxicol In Vitro ; 46: 29-38, 2018 Feb.
Article in En | MEDLINE | ID: mdl-28919358
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mitochondria, Liver / Hazardous Substances / Hepatocytes / Chemical and Drug Induced Liver Injury Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Toxicol In Vitro Journal subject: TOXICOLOGIA Year: 2018 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mitochondria, Liver / Hazardous Substances / Hepatocytes / Chemical and Drug Induced Liver Injury Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Toxicol In Vitro Journal subject: TOXICOLOGIA Year: 2018 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido