A Redox Modulatory Mn3 O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model.
Angew Chem Int Ed Engl
; 56(45): 14267-14271, 2017 11 06.
Article
in En
| MEDLINE
| ID: mdl-28922532
ABSTRACT
Nanomaterials with enzyme-like activities (nanozymes) attracts significant interest due to their therapeutic potential for the treatment of various diseases. Herein, we report that a Mn3 O4 nanozyme functionally mimics three major antioxidant enzymes, that is, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the multienzyme activity is size as well as morphology-dependent. The redox modulatory effect of Mn3 O4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)-like cellular model, indicating that manganese-based nanomaterials having multi-enzyme activity can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxides
/
Parkinson Disease
/
Superoxide Dismutase
/
Catalase
/
Manganese Compounds
/
Cytoprotection
/
Nanostructures
/
Glutathione Peroxidase
Limits:
Humans
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2017
Document type:
Article
Affiliation country:
India