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Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells.
Megiorni, Francesca; Gravina, Giovanni Luca; Camero, Simona; Ceccarelli, Simona; Del Fattore, Andrea; Desiderio, Vincenzo; Papaccio, Federica; McDowell, Heather P; Shukla, Rajeev; Pizzuti, Antonio; Beirinckx, Filip; Pujuguet, Philippe; Saniere, Laurent; der Aar, Ellen Van; Maggio, Roberto; De Felice, Francesca; Marchese, Cinzia; Dominici, Carlo; Tombolini, Vincenzo; Festuccia, Claudio; Marampon, Francesco.
Affiliation
  • Megiorni F; Department of Paediatrics and Infantile Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy. francesca.megiorni@uniroma1.it.
  • Gravina GL; Department of Biotechnological and Applied Clinical Sciences, Division of Radiation Oncology, University of L'Aquila, L'Aquila, Italy.
  • Camero S; Department of Paediatrics and Infantile Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy.
  • Ceccarelli S; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Del Fattore A; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Desiderio V; Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy.
  • Papaccio F; Department of Experimental Medicine, Section of Biotechnology and Medical Histology and Embriology, Second University of Naples, Naples, Italy.
  • McDowell HP; Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery "F. Magrassi A. Lanzara", Second University of Naples, Naples, Italy.
  • Shukla R; Department of Paediatrics and Infantile Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy.
  • Pizzuti A; Department of Oncology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
  • Beirinckx F; Department of Perinatal and Paediatric Pathology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
  • Pujuguet P; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Saniere L; Galapagos NV, Industriepark Mechelen Noord, General De Wittelaan L11 A3, 2880, Mechelen, Belgium.
  • der Aar EV; Galapagos France, 102 avenue Gaston Roussel, 93230, Romainville, France.
  • Maggio R; Galapagos France, 102 avenue Gaston Roussel, 93230, Romainville, France.
  • De Felice F; Galapagos NV, Industriepark Mechelen Noord, General De Wittelaan L11 A3, 2880, Mechelen, Belgium.
  • Marchese C; Department of Biotechnological and Applied Clinical Sciences, Division of Pharmacology, University of L'Aquila, L'Aquila, Italy.
  • Dominici C; Department of Radiological, Oncological and Pathological Sciences, "Sapienza" University of Rome, Rome, Italy.
  • Tombolini V; Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Festuccia C; Department of Paediatrics and Infantile Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy.
  • Marampon F; Department of Radiological, Oncological and Pathological Sciences, "Sapienza" University of Rome, Rome, Italy.
J Hematol Oncol ; 10(1): 161, 2017 10 06.
Article in En | MEDLINE | ID: mdl-28985758
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rhabdomyosarcoma, Embryonal / Receptors, Eph Family Limits: Adolescent / Animals / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Language: En Journal: J Hematol Oncol Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2017 Document type: Article Affiliation country: Italia Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rhabdomyosarcoma, Embryonal / Receptors, Eph Family Limits: Adolescent / Animals / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Language: En Journal: J Hematol Oncol Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2017 Document type: Article Affiliation country: Italia Country of publication: Reino Unido