Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus.

Sato, Yusuke; Matsui, Hideki; Yamamoto, Naoki; Sato, Risa; Munakata, Tsubasa; Kohara, Michinori; Harashima, Hideyoshi

Sato, Yusuke; Matsui, Hideki; Yamamoto, Naoki; Sato, Risa; Munakata, Tsubasa; Kohara, Michinori; Harashima, Hideyoshi.

Affiliation

Sato Y; Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo 060-0812, Japan.
Matsui H; Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo 060-0812, Japan.
Yamamoto N; Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Sato R; Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo 060-0812, Japan.
Munakata T; Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Kohara M; Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Harashima H; Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo 060-0812, Japan. Electronic address: harasima@pharm.hokudai.ac.jp.

J Control Release ; 266: 216-225, 2017 Nov 28.

Article in En | MEDLINE | ID: mdl-28986168

Subject(s)
Key words

Active target; Lipid nanoparticles; Persistent HBV infection; Safety; siRNA delivery

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatitis B virus / Hepatocytes / RNA, Small Interfering Type of study: Risk_factors_studies Limits: Animals Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2017 Document type: Article Affiliation country: Japón Country of publication: Países Bajos

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