Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow.
Braz J Med Biol Res
; 50(12): e6087, 2017 Oct 19.
Article
in En
| MEDLINE
| ID: mdl-29069221
ABSTRACT
Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with 25 mg iron dextran every 3 days for 4 weeks to establish an iron overload (Fe) model. DFX or NAC were co-administered with iron dextran in two groups of mice (Fe+DFX and Fe+NAC), and the function of HSPCs was then examined. Iron overload markedly decreased the number of murine HSPCs in bone marrow. Subsequent colony-forming cell assays showed that iron overload also decreased the colony forming capacity of HSPCs, the effect of which could be reversed by DFX and NAC. The bone marrow hematopoiesis damage caused by iron overload could be alleviated by DFX and NAC.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acetylcysteine
/
Triazoles
/
Benzoates
/
Hematopoietic Stem Cells
/
Iron Chelating Agents
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Free Radical Scavengers
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Iron Overload
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Protective Agents
Type of study:
Evaluation_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Braz J Med Biol Res
Year:
2017
Document type:
Article
Affiliation country:
China