Modeling neurological diseases using iPSC-derived neural cells : iPSC modeling of neurological diseases.
Cell Tissue Res
; 371(1): 143-151, 2018 01.
Article
in En
| MEDLINE
| ID: mdl-29079884
ABSTRACT
Developing efficient models for neurological diseases enables us to uncover disease mechanisms and develop therapeutic strategies to treat them. Discovery of reprogramming somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the way of modeling human diseases, especially neurological diseases. Currently almost all types of neural cells, including but not limited to neural stem cells, neurons, astrocytes, oligodendrocytes and microglia, can be derived from iPSCs following developmental principles. These iPSC-derived neural cells provide valuable tools for studying neurological disease mechanisms, developing potential therapies, and deepening our understanding of the nervous system.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Induced Pluripotent Stem Cells
/
Neural Stem Cells
/
Models, Neurological
/
Nervous System Diseases
Limits:
Animals
/
Humans
Language:
En
Journal:
Cell Tissue Res
Year:
2018
Document type:
Article
Affiliation country:
Estados Unidos