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Cumulus cells surrounding oocytes with high developmental competence exhibit down-regulation of phosphoinositol 1,3 kinase/protein kinase B (PI3K/AKT) signalling genes involved in proliferation and survival.
Artini, P G; Tatone, C; Sperduti, S; D'Aurora, M; Franchi, S; Di Emidio, G; Ciriminna, R; Vento, M; Di Pietro, C; Stuppia, L; Gatta, V.
Affiliation
  • Artini PG; Department of Clinical and Experimental Medicine, Division of Obstetrics and Gynecology Oncology, University of Pisa, Via Savi 10, 56126 Pisa, Italy.
  • Tatone C; Department of Life, Health and Environmental Sciences, University of L'Aquila, Piazzale Salvatore Tommasi 1, 67100 L'Aquila, Italy.
  • Sperduti S; Functional Genetics Unit, Center of Excellence on Aging (Ce.S.I.-Met), Via Dei Vestini 31, 66100 Chieti, Italy.
  • D'Aurora M; Functional Genetics Unit, Center of Excellence on Aging (Ce.S.I.-Met), Via Dei Vestini 31, 66100 Chieti, Italy.
  • Franchi S; Department of Psychological, Health and Territorial Sciences, School of Medicine and Health Sciences, 'G.d'Annunzio' University, Via Dei Vestini 31, 66100 Chieti, Italy.
  • Di Emidio G; Functional Genetics Unit, Center of Excellence on Aging (Ce.S.I.-Met), Via Dei Vestini 31, 66100 Chieti, Italy.
  • Ciriminna R; Department of Psychological, Health and Territorial Sciences, School of Medicine and Health Sciences, 'G.d'Annunzio' University, Via Dei Vestini 31, 66100 Chieti, Italy.
  • Vento M; Department of Life, Health and Environmental Sciences, University of L'Aquila, Piazzale Salvatore Tommasi 1, 67100 L'Aquila, Italy.
  • Di Pietro C; AMBRA-Associazione Medici e Biologi per la Riproduzione Assistita, Palermo, Italy.
  • Stuppia L; IVF Unit, Cannizzaro Hospital, Catania, Italy.
  • Gatta V; Department of Biomedical Sciences and Biotechnolgy, Section of Biology and Genetics G. Sichel, University of Catania, Via S.Sofia, 87, 95123 Catania, Italy.
Hum Reprod ; 32(12): 2474-2484, 2017 Dec 01.
Article in En | MEDLINE | ID: mdl-29087515
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oocytes / Gene Expression Regulation, Developmental / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt / Cumulus Cells Type of study: Prognostic_studies Limits: Adult / Animals / Female / Humans Language: En Journal: Hum Reprod Journal subject: MEDICINA REPRODUTIVA Year: 2017 Document type: Article Affiliation country: Italia Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oocytes / Gene Expression Regulation, Developmental / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt / Cumulus Cells Type of study: Prognostic_studies Limits: Adult / Animals / Female / Humans Language: En Journal: Hum Reprod Journal subject: MEDICINA REPRODUTIVA Year: 2017 Document type: Article Affiliation country: Italia Country of publication: Reino Unido