[Pharmacokinetics and oral bioavailability of palmatine and jatrorrhizine in Huangteng in rats].
Zhongguo Zhong Yao Za Zhi
; 42(14): 2773-2778, 2017 Jul.
Article
in Zh
| MEDLINE
| ID: mdl-29098836
ABSTRACT
In this study, the total alkaloids of Huangteng were given to the rats by the methods of intragastric administration and tail vein. After the concentration changes of palmatine and jatrorrhizine in the plasma of rats were determined by RP-HPLC, pharmacokinetic parameters and oral bioavailability were calculated by 3P97 software. After the rats were pre-treated with total alkaloid 60 mgâ¢kg⻹ by the methods of intragastric administration and tail vein, the main pharmacokinetic parameters were determined as followsï¼ in the intragastric administration group, the Cmax of palmatine and jatrorrhizine were (0.91±0.06), (0.70±0.08) mgâ¢L⻹; tmax of palmatine and jatrorrhizine were (35.24±0.83), (47.76±1.24) min; t1/2 of palmatine and jatrorrhizine were (187.03±1.53), (105.64±16.99) min, AUC of palmatine and jatrorrhizine were (280.30±18.69), (144.36±1.06) mgâ¢minâ¢L⻹; in the intravenous injection group, the t1/2 of palmatine and jatrorrhizine were (172.18±12.38), (147.26±1.82) min; AUC of palmatine and jatrorrhizine were (2 553.14±214.91), (328.83±10.81) mgâ¢minâ¢L⻹. The oral bioavailability of palmatine was 10.98% and jatrorrhizine was 43.90%.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Berberine
/
Berberine Alkaloids
/
Drugs, Chinese Herbal
Limits:
Animals
Language:
Zh
Journal:
Zhongguo Zhong Yao Za Zhi
Journal subject:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Year:
2017
Document type:
Article
Affiliation country:
China