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Naringenin induces mitochondria-mediated apoptosis and endoplasmic reticulum stress by regulating MAPK and AKT signal transduction pathways in endometriosis cells.
Park, Sunwoo; Lim, Whasun; Bazer, Fuller W; Song, Gwonhwa.
Affiliation
  • Park S; Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Rm 310, Life Science Building (West), 145, Anam-ro, Seongbuk-gu, Seoul, Republic of Korea.
  • Lim W; Department of Biomedical Sciences, Catholic Kwandong University, Rm 420, Cheongsong Building, 24, Beomil-ro 579beon-gil, Gangneung-si, Republic of Korea.
  • Bazer FW; Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A&M University, Rm 442D, Kleberg Center, College Station, TX, USA.
  • Song G; Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Rm 310, Life Science Building (West), 145, Anam-ro, Seongbuk-gu, Seoul, Republic of Korea.
Mol Hum Reprod ; 23(12): 842-854, 2017 12 01.
Article in En | MEDLINE | ID: mdl-29121349
Subject(s)
Endoplasmic Reticulum Stress/drug effects; Estrogen Antagonists/pharmacology; Flavanones/pharmacology; Mitochondria/drug effects; Mitogen-Activated Protein Kinases/genetics; Stromal Cells/drug effects; Annexin A5/genetics; Annexin A5/metabolism; Apoptosis/drug effects; Cell Line; Dose-Response Relationship, Drug; Endometriosis/metabolism; Endometriosis/pathology; Endometrium/metabolism; Endometrium/pathology; Endoplasmic Reticulum Chaperone BiP; Endoribonucleases/genetics; Endoribonucleases/metabolism; Eukaryotic Initiation Factor-2/agonists; Eukaryotic Initiation Factor-2/genetics; Eukaryotic Initiation Factor-2/metabolism; Female; Gene Expression Regulation; Heat-Shock Proteins/agonists; Heat-Shock Proteins/genetics; Heat-Shock Proteins/metabolism; Humans; Membrane Potential, Mitochondrial/drug effects; Mitochondria/metabolism; Mitogen-Activated Protein Kinases/metabolism; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/metabolism; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Reactive Oxygen Species/agonists; Reactive Oxygen Species/metabolism; Signal Transduction; Stromal Cells/metabolism; Stromal Cells/pathology; Transcription Factor CHOP/agonists; Transcription Factor CHOP/genetics; Transcription Factor CHOP/metabolism; bcl-2 Homologous Antagonist-Killer Protein/agonists; bcl-2 Homologous Antagonist-Killer Protein/genetics; bcl-2 Homologous Antagonist-Killer Protein/metabolism; bcl-2-Associated X Protein/agonists; bcl-2-Associated X Protein/genetics; bcl-2-Associated X Protein/metabolism
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stromal Cells / Mitogen-Activated Protein Kinases / Flavanones / Estrogen Antagonists / Endoplasmic Reticulum Stress / Mitochondria Language: En Journal: Mol Hum Reprod Journal subject: BIOLOGIA MOLECULAR / MEDICINA REPRODUTIVA Year: 2017 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stromal Cells / Mitogen-Activated Protein Kinases / Flavanones / Estrogen Antagonists / Endoplasmic Reticulum Stress / Mitochondria Language: En Journal: Mol Hum Reprod Journal subject: BIOLOGIA MOLECULAR / MEDICINA REPRODUTIVA Year: 2017 Document type: Article