Chemical Burns of the Eye: The Role of Retinal Injury and New Therapeutic Possibilities.
Cornea
; 37(2): 248-251, 2018 Feb.
Article
in En
| MEDLINE
| ID: mdl-29135604
ABSTRACT
PURPOSE:
To propose a new treatment paradigm for chemical burns to the eye - in the acute and chronic phases.METHODS:
Recent laboratory and clinical data on the biology and treatment of chemical burns are analyzed.RESULTS:
Corneal blindness from chemical burns can now be successfully treated with a keratoprosthesis, on immediate and intermediate bases. Long term outcomes, however, are hampered by early retinal damage causing glaucoma. New data suggest that rapid diffusion of inflammatory cytokines posteriorly (TNF-α, etc) can severely damage the ganglion cells. Prompt anti-TNF-α treatment is markedly neuroprotective. Long term profound reduction of the intraocular pressure is also vital.CONCLUSION:
A new regimen, in addition to standard treatment, for severe chemical burns is proposed. This involves tumor necrosis factor alpha (TNF-α) inhibition promptly after the accident (primarily for retinal neuroprotection), prophylactic maximal lowering of the intraocular pressure (starting immediately), and keratoprosthesis implantation in a later quiet state.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retina
/
Retinal Diseases
/
Burns, Chemical
Limits:
Humans
Language:
En
Journal:
Cornea
Year:
2018
Document type:
Article
Affiliation country:
Marruecos