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Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased NaV1.5 current and mechanosensitivity.
Strege, Peter R; Mazzone, Amelia; Bernard, Cheryl E; Neshatian, Leila; Gibbons, Simon J; Saito, Yuri A; Tester, David J; Calvert, Melissa L; Mayer, Emeran A; Chang, Lin; Ackerman, Michael J; Beyder, Arthur; Farrugia, Gianrico.
Affiliation
  • Strege PR; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.
  • Mazzone A; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.
  • Bernard CE; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.
  • Neshatian L; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.
  • Gibbons SJ; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.
  • Saito YA; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.
  • Tester DJ; Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic , Rochester, Minnesota.
  • Calvert ML; Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic , Rochester, Minnesota.
  • Mayer EA; Oppenheimer Center for Neurobiology of Stress and Resilience, Division of Digestive Diseases, University of California Los Angeles , Los Angeles, California.
  • Chang L; Oppenheimer Center for Neurobiology of Stress and Resilience, Division of Digestive Diseases, University of California Los Angeles , Los Angeles, California.
  • Ackerman MJ; Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic , Rochester, Minnesota.
  • Beyder A; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.
  • Farrugia G; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.
Am J Physiol Gastrointest Liver Physiol ; 314(4): G494-G503, 2018 04 01.
Article in En | MEDLINE | ID: mdl-29167113
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocytes, Smooth Muscle / Gastrointestinal Tract / Irritable Bowel Syndrome / NAV1.5 Voltage-Gated Sodium Channel Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Am J Physiol Gastrointest Liver Physiol Journal subject: FISIOLOGIA / GASTROENTEROLOGIA Year: 2018 Document type: Article Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocytes, Smooth Muscle / Gastrointestinal Tract / Irritable Bowel Syndrome / NAV1.5 Voltage-Gated Sodium Channel Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Am J Physiol Gastrointest Liver Physiol Journal subject: FISIOLOGIA / GASTROENTEROLOGIA Year: 2018 Document type: Article Country of publication: Estados Unidos