DNA replication stress and cancer chemotherapy.
Cancer Sci
; 109(2): 264-271, 2018 Feb.
Article
in En
| MEDLINE
| ID: mdl-29168596
DNA replication is one of the fundamental biological processes in which dysregulation can cause genome instability. This instability is one of the hallmarks of cancer and confers genetic diversity during tumorigenesis. Numerous experimental and clinical studies have indicated that most tumors have experienced and overcome the stresses caused by the perturbation of DNA replication, which is also referred to as DNA replication stress (DRS). When we consider therapeutic approaches for tumors, it is important to exploit the differences in DRS between tumor and normal cells. In this review, we introduce the current understanding of DRS in tumors and discuss the underlying mechanism of cancer therapy from the aspect of DRS.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genomic Instability
/
DNA Replication
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Cancer Sci
Year:
2018
Document type:
Article
Affiliation country:
Japón
Country of publication:
Reino Unido