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DPI-289, a novel mixed delta opioid agonist / mu opioid antagonist (DAMA), has L-DOPA-sparing potential in Parkinson's disease.
Johnston, Tom H; Versi, Eboo; Howson, Patrick A; Ravenscroft, Paula; Fox, Susan H; Hill, Michael P; Reidenberg, Bruce E; Corey, Ronald; Brotchie, Jonathan M.
Affiliation
  • Johnston TH; Atuka Inc.,Toronto, ON, Canada; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, Canada. Electronic address: t.johnston@atuka.com.
  • Versi E; Dina Pharmaceuticals Inc., Durham, NC, USA; Robert Wood Johnson Medical School, NJ, USA.
  • Howson PA; Atuka Inc.,Toronto, ON, Canada; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, Canada.
  • Ravenscroft P; Atuka Inc.,Toronto, ON, Canada; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, Canada.
  • Fox SH; Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Toronto, Canada.
  • Hill MP; Atuka Inc.,Toronto, ON, Canada; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, Canada.
  • Reidenberg BE; Dept. of Pharmacology, Weill Cornell Medicine, New York, NY, USA.
  • Corey R; Dina Pharmaceuticals Inc., Durham, NC, USA.
  • Brotchie JM; Atuka Inc.,Toronto, ON, Canada; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, Canada.
Neuropharmacology ; 131: 116-127, 2018 03 15.
Article in En | MEDLINE | ID: mdl-29197517
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Piperazines / Benzamides / Levodopa / Receptors, Opioid, delta / Receptors, Opioid, mu / Dyskinesia, Drug-Induced / Narcotic Antagonists Type of study: Etiology_studies Limits: Animals Language: En Journal: Neuropharmacology Year: 2018 Document type: Article Country of publication: Reino Unido
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Piperazines / Benzamides / Levodopa / Receptors, Opioid, delta / Receptors, Opioid, mu / Dyskinesia, Drug-Induced / Narcotic Antagonists Type of study: Etiology_studies Limits: Animals Language: En Journal: Neuropharmacology Year: 2018 Document type: Article Country of publication: Reino Unido