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Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics.
Avery, Lindsay B; Wade, Jason; Wang, Mengmeng; Tam, Amy; King, Amy; Piche-Nicholas, Nicole; Kavosi, Mania S; Penn, Steve; Cirelli, David; Kurz, Jeffrey C; Zhang, Minlei; Cunningham, Orla; Jones, Rhys; Fennell, Brian J; McDonnell, Barry; Sakorafas, Paul; Apgar, James; Finlay, William J; Lin, Laura; Bloom, Laird; O'Hara, Denise M.
Affiliation
  • Avery LB; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA.
  • Wade J; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA.
  • Wang M; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA.
  • Tam A; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA.
  • King A; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA.
  • Piche-Nicholas N; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA.
  • Kavosi MS; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA.
  • Penn S; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA.
  • Cirelli D; c Medicine Design, Pfizer Inc. , Cambridge , MA , USA.
  • Kurz JC; d Pharmaceutical Sciences, Pfizer Inc. , Andover , MA , USA.
  • Zhang M; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA.
  • Cunningham O; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA.
  • Jones R; e Biomedicine Design, Pfizer Inc. , Dublin , Ireland.
  • Fennell BJ; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA.
  • McDonnell B; f Currently Medicine Design, Pfizer Inc. , La Jolla , CA , USA.
  • Sakorafas P; e Biomedicine Design, Pfizer Inc. , Dublin , Ireland.
  • Apgar J; e Biomedicine Design, Pfizer Inc. , Dublin , Ireland.
  • Finlay WJ; d Pharmaceutical Sciences, Pfizer Inc. , Andover , MA , USA.
  • Lin L; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA.
  • Bloom L; e Biomedicine Design, Pfizer Inc. , Dublin , Ireland.
  • O'Hara DM; g Currently CodeBase , Edinburgh , UK.
MAbs ; 10(2): 244-255, 2018.
Article in En | MEDLINE | ID: mdl-29271699
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: In Vitro Techniques / Models, Animal / Drug Discovery / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: MAbs Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
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Print
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: In Vitro Techniques / Models, Animal / Drug Discovery / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: MAbs Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos