Bacterial co-infection and early mortality among pulmonary tuberculosis patients in Manila, The Philippines.
Int J Tuberc Lung Dis
; 22(1): 65-72, 2018 01 01.
Article
in En
| MEDLINE
| ID: mdl-29297428
ABSTRACT
OBJECTIVE:
To investigate the prevalence of bacterial co-infection and its effect on early mortality among hospitalised human immunodeficiency virus (HIV) negative pulmonary tuberculosis (PTB) patients in Manila, the Philippines.DESIGN:
A prospective observational study was conducted at a national infectious disease hospital. HIV-negative PTB patients aged î¶13 years hospitalised from November to December 2011 and from December 2012 to May 2013 were enrolled. Sputum samples were tested for Mycobacterium tuberculosis and six respiratory bacterial pathogens using polymerase chain reaction (PCR).RESULTS:
Of 466 patients, 228 (48.9%) were TB-PCR-positive. Overall, bacterial pathogens in purulent sputum were detected in 135 (29.0%) patients Haemophilus influenzae was the most common bacterium (21.2%), followed by Streptococcus pneumoniae (7.9%). The prevalence of bacterial co-infection did not differ between TB-PCR-positive and -negative patients. A total of 92 (19.7%) patients died within 2 weeks. Bacterial co-infection was significantly associated with an increased risk of 2-week mortality among TB-PCR-positive patients (adjusted risk ratio [aRR] 1.67, 95%CI 1.03-2.72). This association was also observed but did not reach statistical significance among TB-PCR-negative patients (aRR1.7, 95%CI 0.95-3.02).CONCLUSION:
Bacterial co-infection is common and contributes to an increased risk of early mortality among HIV-negative PTB patients.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacterial Infections
/
Tuberculosis, Pulmonary
/
Mycobacterium tuberculosis
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Int J Tuberc Lung Dis
Year:
2018
Document type:
Article
Affiliation country:
Japón
Publication country:
FR
/
FRANCE
/
FRANCIA
/
FRANÇA