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Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases.
Fellows, Rachel; Denizot, Jérémy; Stellato, Claudia; Cuomo, Alessandro; Jain, Payal; Stoyanova, Elena; Balázsi, Szabina; Hajnády, Zoltán; Liebert, Anke; Kazakevych, Juri; Blackburn, Hector; Corrêa, Renan Oliveira; Fachi, José Luís; Sato, Fabio Takeo; Ribeiro, Willian R; Ferreira, Caroline Marcantonio; Perée, Hélène; Spagnuolo, Mariangela; Mattiuz, Raphaël; Matolcsi, Csaba; Guedes, Joana; Clark, Jonathan; Veldhoen, Marc; Bonaldi, Tiziana; Vinolo, Marco Aurélio Ramirez; Varga-Weisz, Patrick.
Affiliation
  • Fellows R; Nuclear Dynamics, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Denizot J; Nuclear Dynamics, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Stellato C; Université Clermont Auvergne, Inserm U1071, INRA USC2018, M2iSH, Clermont-Ferrand, F-63000, France.
  • Cuomo A; Nuclear Dynamics, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Jain P; Department of Experimental Oncology, Istituto Europeo di Oncologia, 20139, Milano, Italy.
  • Stoyanova E; Nuclear Dynamics, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Balázsi S; Nuclear Dynamics, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Hajnády Z; Nuclear Dynamics, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Liebert A; Nuclear Dynamics, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Kazakevych J; Nuclear Dynamics, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Blackburn H; Nuclear Dynamics, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Corrêa RO; Nuclear Dynamics, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Fachi JL; Laboratory of Immunoinflammation, Institute of Biology, UNICAMP, Campinas, 13083-862, Brazil.
  • Sato FT; Laboratory of Immunoinflammation, Institute of Biology, UNICAMP, Campinas, 13083-862, Brazil.
  • Ribeiro WR; Laboratory of Immunoinflammation, Institute of Biology, UNICAMP, Campinas, 13083-862, Brazil.
  • Ferreira CM; Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo, Diadema, SP, 09913-03, Brazil.
  • Perée H; Chemical Biology Graduate Program, Universidade Federal de São Paulo, Diadema, SP, 09913-03, Brazil.
  • Spagnuolo M; Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo, Diadema, SP, 09913-03, Brazil.
  • Mattiuz R; Nuclear Dynamics, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Matolcsi C; Nuclear Dynamics, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Guedes J; Nuclear Dynamics, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Clark J; Nuclear Dynamics, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Veldhoen M; Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Bonaldi T; Biological Chemistry, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Vinolo MAR; Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB22 3AT, UK.
  • Varga-Weisz P; Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, 1649-028, Portugal.
Nat Commun ; 9(1): 105, 2018 01 09.
Article in En | MEDLINE | ID: mdl-29317660
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crotonates / Histones / Fatty Acids, Volatile / Histone Deacetylases / Intestinal Mucosa Limits: Animals / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2018 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crotonates / Histones / Fatty Acids, Volatile / Histone Deacetylases / Intestinal Mucosa Limits: Animals / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2018 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido