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High-efficiency X-ray luminescence in Eu3+-activated tungstate nanoprobes for optical imaging through energy transfer sensitization.
Guo, Tao; Lin, Yan; Zhang, Wei-Jian; Hong, Jin-Sheng; Lin, Ru-Hui; Wu, Xiao-Ping; Li, Juan; Lu, Chun-Hua; Yang, Huang-Hao.
Affiliation
  • Guo T; Key Laboratory for Analytical Science of Food Safety and Biology of the MOE, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350116, P. R. China. chunhualu@fzu.edu.cn hhyang@fzu.edu.cn.
Nanoscale ; 10(4): 1607-1612, 2018 Jan 25.
Article in En | MEDLINE | ID: mdl-29323363
X-ray luminescence optical imaging has been recognized as a powerful technique for medical diagnosis due to its deep penetration and low auto-fluorescence in tissues. However, the low luminescence efficiency of current X-ray luminescence nanoprobes remains a major hurdle for sensitive bioimaging in practical medical applications. Here we present a new kind of energy transfer-sensitized X-ray luminescence nanoprobe (PEG-NaGd(WO4)2:Eu) for highly effective optical bioimaging. Under X-ray excitation, the tungstate host absorbs the X-ray photons and then transfers the energy to the Eu3+ luminescence center, thus enhancing the luminescence efficiency of the nanoprobes for high sensitivity optical in vivo imaging. Moreover, the shortened T1 relaxation response of Gd3+ ions and X-ray attenuation capability of W atoms enable the nanoprobes to serve as efficient contrast agents for magnetic resonance imaging (MRI) and computed tomography (CT) imaging. Therefore, combined with the MRI, CT and X-ray luminescence imaging capabilities, the present PEG-NaGd(WO4)2:Eu nanoprobes could be used as promising multimodal imaging contrast agents in biological systems.

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Nanoscale Year: 2018 Document type: Article Country of publication: Reino Unido

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Nanoscale Year: 2018 Document type: Article Country of publication: Reino Unido