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Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk.
Dalke, Claudia; Neff, Frauke; Bains, Savneet Kaur; Bright, Scott; Lord, Deborah; Reitmeir, Peter; Rößler, Ute; Samaga, Daniel; Unger, Kristian; Braselmann, Herbert; Wagner, Florian; Greiter, Matthias; Gomolka, Maria; Hornhardt, Sabine; Kunze, Sarah; Kempf, Stefan J; Garrett, Lillian; Hölter, Sabine M; Wurst, Wolfgang; Rosemann, Michael; Azimzadeh, Omid; Tapio, Soile; Aubele, Michaela; Theis, Fabian; Hoeschen, Christoph; Slijepcevic, Predrag; Kadhim, Munira; Atkinson, Michael; Zitzelsberger, Horst; Kulka, Ulrike; Graw, Jochen.
Affiliation
  • Dalke C; Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, 85764, Neuherberg, Germany.
  • Neff F; Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Pathology, Neuherberg, Germany.
  • Bains SK; Municipal Clinical Center Munich, Munich, Germany.
  • Bright S; Department of Life Sciences, Brunel University London, Uxbridge, UK.
  • Lord D; Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.
  • Reitmeir P; Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.
  • Rößler U; University of Texas, MD Anderson, Houston, TX, USA.
  • Samaga D; Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.
  • Unger K; Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Health Economics and Health Care Management, Neuherberg, Germany.
  • Braselmann H; Department Radiation Protection and Health, Federal Office for Radiation Protection, Oberschleissheim, Germany.
  • Wagner F; Department Radiation Protection and Health, Federal Office for Radiation Protection, Oberschleissheim, Germany.
  • Greiter M; Helmholtz Center Munich, German Research Center for Environmental Health, Research Unit of Radiation Cytogenetics, Neuherberg, Germany.
  • Gomolka M; Helmholtz Center Munich, German Research Center for Environmental Health, Research Unit of Radiation Cytogenetics, Neuherberg, Germany.
  • Hornhardt S; Helmholtz Center Munich, German Research Center for Environmental Health, Research Unit of Radiation Cytogenetics, Neuherberg, Germany.
  • Kunze S; Helmholtz Center Munich, German Research Center for Environmental Health, Research Unit Medical Radiation Physics and Diagnostics, Neuherberg, Germany.
  • Kempf SJ; Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Radiation Protection, Neuherberg, Germany.
  • Garrett L; Helmholtz Center Munich, German Research Center for Environmental Health, Research Unit Medical Radiation Physics and Diagnostics, Neuherberg, Germany.
  • Hölter SM; Helmholtz Center Munich, German Research Center for Environmental Health, Individual Monitoring Service, Neuherberg, Germany.
  • Wurst W; Department Radiation Protection and Health, Federal Office for Radiation Protection, Oberschleissheim, Germany.
  • Rosemann M; Department Radiation Protection and Health, Federal Office for Radiation Protection, Oberschleissheim, Germany.
  • Azimzadeh O; Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, 85764, Neuherberg, Germany.
  • Tapio S; Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Radiation Biology, Neuherberg, Germany.
  • Aubele M; Department of Bioanalytical Sciences, CSL Behring GmbH, Marburg, Germany.
  • Theis F; Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, 85764, Neuherberg, Germany.
  • Hoeschen C; Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, 85764, Neuherberg, Germany.
  • Slijepcevic P; Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, 85764, Neuherberg, Germany.
  • Kadhim M; Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Radiation Biology, Neuherberg, Germany.
  • Atkinson M; Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Radiation Biology, Neuherberg, Germany.
  • Zitzelsberger H; Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Radiation Biology, Neuherberg, Germany.
  • Kulka U; Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Pathology, Neuherberg, Germany.
  • Graw J; Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany.
Radiat Environ Biophys ; 57(2): 99-113, 2018 05.
Article in En | MEDLINE | ID: mdl-29327260
ABSTRACT
Because of the increasing application of ionizing radiation in medicine, quantitative data on effects of low-dose radiation are needed to optimize radiation protection, particularly with respect to cataract development. Using mice as mammalian animal model, we applied a single dose of 0, 0.063, 0.125 and 0.5 Gy at 10 weeks of age, determined lens opacities for up to 2 years and compared it with overall survival, cytogenetic alterations and cancer development. The highest dose was significantly associated with increased body weight and reduced survival rate. Chromosomal aberrations in bone marrow cells showed a dose-dependent increase 12 months after irradiation. Pathological screening indicated a dose-dependent risk for several types of tumors. Scheimpflug imaging of the lens revealed a significant dose-dependent effect of 1% of lens opacity. Comparison of different biological end points demonstrated long-term effects of low-dose irradiation for several biological end points.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiation Injuries, Experimental / Cataract Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Radiat Environ Biophys Year: 2018 Document type: Article Affiliation country: Alemania
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiation Injuries, Experimental / Cataract Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Radiat Environ Biophys Year: 2018 Document type: Article Affiliation country: Alemania