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Variability and reliability of POP concentrations in multiple breast milk samples collected from the same mothers.
Kakimoto, Risa; Ichiba, Masayoshi; Matsumoto, Akiko; Nakai, Kunihiko; Tatsuta, Nozomi; Iwai-Shimada, Miyuki; Ishiyama, Momoko; Ryuda, Noriko; Someya, Takashi; Tokumoto, Ieyasu; Ueno, Daisuke.
Affiliation
  • Kakimoto R; Department of Environmental Science, Graduate School of Agriculture, Saga University, Honjo 1, Saga, 840-8502, Japan.
  • Ichiba M; Department of Social Medicine, Saga University School of Medicine, Saga, Japan.
  • Matsumoto A; Department of Social Medicine, Saga University School of Medicine, Saga, Japan.
  • Nakai K; Graduate School of Medicine, Tohoku University, Sendai, Japan.
  • Tatsuta N; Graduate School of Medicine, Tohoku University, Sendai, Japan.
  • Iwai-Shimada M; Center for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Japan.
  • Ishiyama M; Department of Environmental Science, Graduate School of Agriculture, Saga University, Honjo 1, Saga, 840-8502, Japan.
  • Ryuda N; Department of Environmental Science, Graduate School of Agriculture, Saga University, Honjo 1, Saga, 840-8502, Japan.
  • Someya T; Department of Environmental Science, Graduate School of Agriculture, Saga University, Honjo 1, Saga, 840-8502, Japan.
  • Tokumoto I; Department of Environmental Science, Graduate School of Agriculture, Saga University, Honjo 1, Saga, 840-8502, Japan.
  • Ueno D; Department of Environmental Science, Graduate School of Agriculture, Saga University, Honjo 1, Saga, 840-8502, Japan. uenod@cc.saga-u.ac.jp.
Environ Sci Pollut Res Int ; 25(17): 16309-16315, 2018 Jun.
Article in En | MEDLINE | ID: mdl-29332276
Risk assessment of infant using a realistic persistent organic pollutant (POP) exposure through breast milk is essential to devise future regulation of POPs. However, recent investigations have demonstrated that POP levels in breast milk collected from the same mother showed a wide range of variation daily and monthly. To estimate the appropriate sample size of breast milk from the same mother to obtain reliable POP concentrations, breast milk samples were collected from five mothers living in Japan from 2006 to 2012. Milk samples from each mother were collected 3 to 6 times a day through 3 to 7 days consecutively. Food samples as the duplicated method were collected from two mothers during the period of breast milk sample collection. Those were employed for POP (PCBs, DDTs, chlordanes, and HCB) analysis. PCB concentrations detected in breast milk samples showed a wide range of variation which was maximum 63 and 60% of relative standard deviation (RSD) in lipid and wet weight basis, respectively. The time course trend of those variations among the mothers did not show any typical pattern. A larger amount of PCB intake through food seemed to affect 10 h after those concentrations in breast milk in lipid weight basis. Intraclass correlation coefficient (ICC) analyses indicated that the appropriate sample size for good reproducibility of POP concentrations in breast milk required at least two samples for lipid and wet weight basis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chlordan / Polychlorinated Biphenyls / Environmental Pollutants / Milk, Human Type of study: Etiology_studies / Risk_factors_studies Limits: Adult / Female / Humans / Infant Country/Region as subject: Asia Language: En Journal: Environ Sci Pollut Res Int Journal subject: SAUDE AMBIENTAL / TOXICOLOGIA Year: 2018 Document type: Article Affiliation country: Japón Country of publication: Alemania

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chlordan / Polychlorinated Biphenyls / Environmental Pollutants / Milk, Human Type of study: Etiology_studies / Risk_factors_studies Limits: Adult / Female / Humans / Infant Country/Region as subject: Asia Language: En Journal: Environ Sci Pollut Res Int Journal subject: SAUDE AMBIENTAL / TOXICOLOGIA Year: 2018 Document type: Article Affiliation country: Japón Country of publication: Alemania