Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 2. Rational Bioavailability Design by Global Sensitivity Analysis To Identify Properties Affecting Bioavailability.

Daga, Pankaj R; Bolger, Michael B; Haworth, Ian S; Clark, Robert D; Martin, Eric J

Daga, Pankaj R; Bolger, Michael B; Haworth, Ian S; Clark, Robert D; Martin, Eric J.

Affiliation

Daga PR; Novartis Institute of Biomedical Research , Emeryville , California 94608 , United States.
Bolger MB; Simulations Plus, Inc ., 42505 10th Street West , Lancaster , California 93534 , United States.
Haworth IS; Department of Pharmacology and Pharmaceutical Sciences , University of Southern California , Los Angeles , California 90089 , United States.
Clark RD; Simulations Plus, Inc ., 42505 10th Street West , Lancaster , California 93534 , United States.
Martin EJ; Novartis Institute of Biomedical Research , Emeryville , California 94608 , United States.

Mol Pharm ; 15(3): 831-839, 2018 03 05.

Article in En | MEDLINE | ID: mdl-29337562

Subject(s)
Key words

PBPK; PLS; global sensitivity analysis; lead optimization; lead series; local model; multiobjective optimization

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chemistry, Pharmaceutical / Quantitative Structure-Activity Relationship / Enzyme Inhibitors / Drug Discovery / Models, Biological Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2018 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

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