ß-glucans and cholesterol (Review).
Int J Mol Med
; 41(4): 1799-1808, 2018 Apr.
Article
in En
| MEDLINE
| ID: mdl-29393350
ABSTRACT
Hypercholesterolemia is one of primary risk factors of cardiovascular disease, together with metabolic syndrome, hypertension and diabetes. Although progress has been made, the search for novel methods of preventing and treating dyslipidemia is ongoing and current therapies for cardiovascular disease induce various side effects. ßglucans are linear unbranched polysaccharides found in various natural sources, such as mushrooms. Due to their structure they are able to interact with innate immunity receptors, however they also act as dietary fibers in the digestive tract. As there are two forms of ßglucans, insoluble and soluble forms, they are able to interact with lipids and biliary salts in the bowel and consequently reduce cholesterol levels. Therefore, they may be developed as a suitable therapeutic option to treat patients with dyslipidemia, as they are natural molecules that do not induce any significant side effects. The current review discusses the evidence supporting the effects of ßglucans on cholesterol levels.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dietary Fiber
/
Cholesterol
/
Beta-Glucans
/
Hypercholesterolemia
/
Immunologic Factors
/
Anticholesteremic Agents
Type of study:
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Int J Mol Med
Journal subject:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Year:
2018
Document type:
Article
Affiliation country:
República Checa