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Changes in lipid metabolism in pediatric patients with severe sepsis and septic shock.
Bermudes, Ana Carolina G; de Carvalho, Werther B; Zamberlan, Patricia; Muramoto, Giovana; Maranhão, Raul C; Delgado, Artur F.
Affiliation
  • Bermudes ACG; Pediatric Critical Care Unit, Instituto da Criança da Faculdade de Medicina, São Paulo University, São Paulo, Brazil. Electronic address: anacarolgb@yahoo.com.br.
  • de Carvalho WB; Pediatric Critical Care Unit, Instituto da Criança da Faculdade de Medicina, São Paulo University, São Paulo, Brazil.
  • Zamberlan P; Division of Nutrition, Instituto da Criança da Faculdade de Medicina, São Paulo University, São Paulo, Brazil.
  • Muramoto G; Emergency Department, Hospital Universitário, São Paulo University, São Paulo, Brazil.
  • Maranhão RC; Lipid Metabolism Laboratory, Heart Institute (InCor) of the Medical School Hospital, São Paulo University, São Paulo, Brazil.
  • Delgado AF; Pediatric Critical Care Unit, Instituto da Criança da Faculdade de Medicina, São Paulo University, São Paulo, Brazil.
Nutrition ; 47: 104-109, 2018 03.
Article in En | MEDLINE | ID: mdl-29429528
OBJECTIVES: Limited knowledge exists regarding the lipid profiles of critically ill pediatric patients with systemic inflammatory response syndrome. The aim of this study was to evaluate the relationship between the intensity of the inflammatory response and changes in the lipid profiles of critically ill pediatric patients admitted to a pediatric intensive care unit (PICU) with severe sepsis/septic shock. METHODS: This was a prospective and observational study at a 15-bed PICU at a public university hospital. We analyzed the lipid profiles of 40 patients with severe sepsis/septic shock admitted to the PICU on the first and seventh days of hospitalization. C-reactive protein was used as a marker for systemic inflammation. Forty-two pediatric patients seen in the emergency department and without systemic inflammatory response syndrome were used to provide control values. RESULTS: On day 1 of admission to the PICU, the patients had significantly lower levels of total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) as well as higher concentrations of triacylglycerols compared with the control group. There was a significant increase in the TC, HDL, LDL, and apolipoprotein levels from day 1 to day 7 of the study. CONCLUSIONS: During severe sepsis/septic shock, we found lower serum levels of lipoproteins and apolipoproteins, and these were negatively correlated with C-reactive protein. As the inflammatory response improved, the levels of TC, HDL, LDL, and apolipoproteins increased, suggesting a direct relationship between changes in the lipid profiles and inflammation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Patient Admission / Shock, Septic / Sepsis Type of study: Observational_studies Limits: Child, preschool / Female / Humans / Infant / Male Language: En Journal: Nutrition Journal subject: CIENCIAS DA NUTRICAO Year: 2018 Document type: Article Country of publication: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Patient Admission / Shock, Septic / Sepsis Type of study: Observational_studies Limits: Child, preschool / Female / Humans / Infant / Male Language: En Journal: Nutrition Journal subject: CIENCIAS DA NUTRICAO Year: 2018 Document type: Article Country of publication: Estados Unidos