Associations of multiple plasma metals with incident type 2 diabetes in Chinese adults: The Dongfeng-Tongji Cohort.
Environ Pollut
; 237: 917-925, 2018 Jun.
Article
in En
| MEDLINE
| ID: mdl-29429611
ABSTRACT
The long-term associations between multiple metals and incident diabetes are uncertain. We aimed to examine the relationship between plasma concentrations of 23 metals and the incidence of type 2 diabetes among Chinese senior adults. We quantified fasting plasma concentrations of 23 metals by inductively coupled plasma mass spectrometry among 1039 incident diabetes cases and 1039 controls (age and sex matched) nested in a prospective study, the Dongfeng-Tongji cohort. Both cases and controls were free of diabetes at baseline (2008-2010), incident diabetes were identified using the following criteria fasting glucoseâ¯≥â¯7.0â¯mmoL/l; or hemoglobin A1c (HbA1c)â¯≥â¯6.5%; or self-reported physician diagnosis of diabetes or use of anti-diabetic medication during the follow-up visits in 2013. In the conditional logistic regression models, the multivariable adjusted ORs (95% CIs) of diabetes across quartiles (Q1-Q4) of metal concentrations were as follows titanium, 1.00, 0.92, 1.31, 1.38 (1.00-1.91, Ptrendâ¯=â¯0.011); selenium, 1.00, 1.08, 1.45, 1.27 (0.93-1.74, Ptrendâ¯=â¯0.05); and antimony, 1.00, 0.79, 0.77, 0.60 (0.44-0.83, Ptrendâ¯=â¯0.002). Arsenic was significantly associated with diabetes in the crude model (ORs comparing extreme quartiles 1.30; 1.02-1.65; Ptrendâ¯=â¯0.006), but was not significant after adjustment for socio-demographic factors. No significant associations were found for other metals. In conclusion, titanium and selenium were positively while antimony was negatively associated with incident diabetes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Environmental Exposure
/
Environmental Pollutants
/
Metals
Type of study:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Environ Pollut
Journal subject:
SAUDE AMBIENTAL
Year:
2018
Document type:
Article
Affiliation country:
China