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NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Hou, Yujun; Lautrup, Sofie; Cordonnier, Stephanie; Wang, Yue; Croteau, Deborah L; Zavala, Eduardo; Zhang, Yongqing; Moritoh, Kanako; O'Connell, Jennifer F; Baptiste, Beverly A; Stevnsner, Tinna V; Mattson, Mark P; Bohr, Vilhelm A.
Affiliation
  • Hou Y; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
  • Lautrup S; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
  • Cordonnier S; Danish Aging Research Center, Department of Molecular Biology and Genetics, University of Aarhus, 8000 Aarhus C, Denmark.
  • Wang Y; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
  • Croteau DL; Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
  • Zavala E; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
  • Zhang Y; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
  • Moritoh K; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
  • O'Connell JF; Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
  • Baptiste BA; Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
  • Stevnsner TV; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
  • Mattson MP; Danish Aging Research Center, Department of Molecular Biology and Genetics, University of Aarhus, 8000 Aarhus C, Denmark.
  • Bohr VA; Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
Proc Natl Acad Sci U S A ; 115(8): E1876-E1885, 2018 02 20.
Article in En | MEDLINE | ID: mdl-29432159
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Niacinamide / Disease Models, Animal / Alzheimer Disease / NAD Type of study: Prognostic_studies Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Document type: Article Country of publication: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Niacinamide / Disease Models, Animal / Alzheimer Disease / NAD Type of study: Prognostic_studies Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Document type: Article Country of publication: Estados Unidos