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The Integrated Genomic Landscape of Thymic Epithelial Tumors.
Radovich, Milan; Pickering, Curtis R; Felau, Ina; Ha, Gavin; Zhang, Hailei; Jo, Heejoon; Hoadley, Katherine A; Anur, Pavana; Zhang, Jiexin; McLellan, Mike; Bowlby, Reanne; Matthew, Thomas; Danilova, Ludmila; Hegde, Apurva M; Kim, Jaegil; Leiserson, Mark D M; Sethi, Geetika; Lu, Charles; Ryan, Michael; Su, Xiaoping; Cherniack, Andrew D; Robertson, Gordon; Akbani, Rehan; Spellman, Paul; Weinstein, John N; Hayes, D Neil; Raphael, Ben; Lichtenberg, Tara; Leraas, Kristen; Zenklusen, Jean Claude; Fujimoto, Junya; Scapulatempo-Neto, Cristovam; Moreira, Andre L; Hwang, David; Huang, James; Marino, Mirella; Korst, Robert; Giaccone, Giuseppe; Gokmen-Polar, Yesim; Badve, Sunil; Rajan, Arun; Ströbel, Philipp; Girard, Nicolas; Tsao, Ming S; Marx, Alexander; Tsao, Anne S; Loehrer, Patrick J.
Affiliation
  • Radovich M; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA.
  • Pickering CR; MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Felau I; National Cancer Institute, Bethesda, MD 20892, USA.
  • Ha G; Broad Institute, Cambridge, MA 02142, USA.
  • Zhang H; Broad Institute, Cambridge, MA 02142, USA.
  • Jo H; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Hoadley KA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Anur P; Oregon Health & Science University, Portland, OR 97239, USA.
  • Zhang J; MD Anderson Cancer Center, Houston, TX 77030, USA.
  • McLellan M; McDonnell Genome Institute at Washington University, St. Louis, MO 63108, USA.
  • Bowlby R; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
  • Matthew T; University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
  • Danilova L; John Hopkins University, Baltimore, MD 21231, USA.
  • Hegde AM; MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Kim J; Broad Institute, Cambridge, MA 02142, USA.
  • Leiserson MDM; Department of Computer Science & Center for Computational Molecular Biology, Brown University, Providence, RI 02912, USA.
  • Sethi G; Institute for Systems Biology, Seattle, WA 98109, USA.
  • Lu C; McDonnell Genome Institute at Washington University, St. Louis, MO 63108, USA.
  • Ryan M; MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Su X; MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Cherniack AD; Broad Institute, Cambridge, MA 02142, USA.
  • Robertson G; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
  • Akbani R; MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Spellman P; Oregon Health & Science University, Portland, OR 97239, USA.
  • Weinstein JN; MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Hayes DN; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Raphael B; Department of Computer Science & Center for Computational Molecular Biology, Brown University, Providence, RI 02912, USA.
  • Lichtenberg T; Nationwide Children's Hospital, Columbus, OH 43205, USA.
  • Leraas K; Nationwide Children's Hospital, Columbus, OH 43205, USA.
  • Zenklusen JC; National Cancer Institute, Bethesda, MD 20892, USA.
  • Fujimoto J; MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Scapulatempo-Neto C; Pathology Department and Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil.
  • Moreira AL; New York University, New York City, NY 10012, USA.
  • Hwang D; University Health Network, Toronto, ON M5G 2C4, Canada.
  • Huang J; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Marino M; Department of Pathology, Regina Elena National Cancer Institute, Rome 00144, Italy.
  • Korst R; Valley Health System, Ridgewood, NJ 07450, USA.
  • Giaccone G; Georgetown University, Washington, DC 20057, USA.
  • Gokmen-Polar Y; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA.
  • Badve S; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA.
  • Rajan A; National Cancer Institute, Bethesda, MD 20892, USA.
  • Ströbel P; University Medical Center, Göttingen 37075, Germany.
  • Girard N; Institute of Oncology, Cardiobiotec, Hospices Civils de Lyon, Lyon 69002, France.
  • Tsao MS; Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
  • Marx A; University Medical Centre Mannheim, University of Heidelberg, Mannheim 68167, Germany.
  • Tsao AS; MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: astsao@mdanderson.org.
  • Loehrer PJ; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA. Electronic address: ploehrer@iu.edu.
Cancer Cell ; 33(2): 244-258.e10, 2018 02 12.
Article in En | MEDLINE | ID: mdl-29438696
ABSTRACT
Thymic epithelial tumors (TETs) are one of the rarest adult malignancies. Among TETs, thymoma is the most predominant, characterized by a unique association with autoimmune diseases, followed by thymic carcinoma, which is less common but more clinically aggressive. Using multi-platform omics analyses on 117 TETs, we define four subtypes of these tumors defined by genomic hallmarks and an association with survival and World Health Organization histological subtype. We further demonstrate a marked prevalence of a thymoma-specific mutated oncogene, GTF2I, and explore its biological effects on multi-platform analysis. We further observe enrichment of mutations in HRAS, NRAS, and TP53. Last, we identify a molecular link between thymoma and the autoimmune disease myasthenia gravis, characterized by tumoral overexpression of muscle autoantigens, and increased aneuploidy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymoma / Thymus Neoplasms / Neoplasms, Glandular and Epithelial / Transcription Factors, TFII / Mutation Type of study: Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2018 Document type: Article Affiliation country: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymoma / Thymus Neoplasms / Neoplasms, Glandular and Epithelial / Transcription Factors, TFII / Mutation Type of study: Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2018 Document type: Article Affiliation country: Estados Unidos