High levels of an endothelial dysfunction marker (sVCAM-1) are associated with injurious and recurrent falls and mortality over a 5-year interval in an older population.
Exp Gerontol
; 106: 1-7, 2018 06.
Article
in En
| MEDLINE
| ID: mdl-29481968
ABSTRACT
We investigated the association between elevated plasma concentrations of circulating soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) and injurious falls and mortality over a 5-year period. We studied the prospective relationship between levels of circulating adhesion molecules and falls in 680 community-dwelling participants in the MOBILIZE Boston Study. The mean sVCAM-1 (±SD) concentration was 1192⯱â¯428â¯ng/mL. Over 5-years of follow-up, 10.2% of participants died. The baseline sVCAM-1 (±SD) concentration was 1434⯱â¯511â¯ng/mL in those who died vs. 1162⯱â¯402â¯ng/mL in those who survived (Pâ¯<â¯0.0001). sVCAM-1 level was associated with recurrent falls (Pâ¯<â¯0.01); compared to the lowest quintile, the highest quintile of sVCAM-1 was associated with increased risk of injurious falls [multivariable adjusted Incidence Rate Ratioâ¯=â¯1.9, 95% CI (1.2-2.9), Pâ¯=â¯0.009]. On survival analysis, the highest sVCAM-1 quintile was associated with the greatest mortality over 5â¯years (log-rank test, Pâ¯<â¯0.0001). The adjusted hazard ratio was 2.4 [95% CI (2.1-2.7), Pâ¯=â¯0.002]. High sVCAM-1 blood concentration was strongly associated with recurrent falls, injurious falls, and mortality in older adults.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Accidental Falls
/
Mortality
/
Vascular Cell Adhesion Molecule-1
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
America do norte
Language:
En
Journal:
Exp Gerontol
Year:
2018
Document type:
Article