Abnormal mTOR Activation in Autism.
Annu Rev Neurosci
; 41: 1-23, 2018 07 08.
Article
in En
| MEDLINE
| ID: mdl-29490194
The mechanistic target of rapamycin (mTOR) is an important signaling hub that integrates environmental information regarding energy availability and stimulates anabolic molecular processes and cell growth. Abnormalities in this pathway have been identified in several syndromes in which autism spectrum disorder (ASD) is highly prevalent. Several studies have investigated mTOR signaling in developmental and neuronal processes that, when dysregulated, could contribute to the development of ASD. Although many potential mechanisms still remain to be fully understood, these associations are of great interest because of the clinical availability of mTOR inhibitors. Clinical trials evaluating the efficacy of mTOR inhibitors to improve neurodevelopmental outcomes have been initiated.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autistic Disorder
/
Signal Transduction
/
TOR Serine-Threonine Kinases
Limits:
Animals
/
Humans
Language:
En
Journal:
Annu Rev Neurosci
Year:
2018
Document type:
Article
Country of publication:
Estados Unidos