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Exogenous recombinant human thioredoxin-1 prevents acetaminophen-induced liver injury by scavenging oxidative stressors, restoring the thioredoxin-1 system and inhibiting receptor interacting protein-3 overexpression.
Lee, Byung-Woo; Jeon, Byung-Suk; Yoon, Byung-Il.
Affiliation
  • Lee BW; College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, 1 Kangwondaehak-gil, Chuncheon, Gangwon, 24341, Republic of Korea.
  • Jeon BS; Biotoxtech Co., 53 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, 28115, Republic of Korea.
  • Yoon BI; Biotoxtech Co., 53 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, 28115, Republic of Korea.
J Appl Toxicol ; 38(7): 1008-1017, 2018 07.
Article in En | MEDLINE | ID: mdl-29512171
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thioredoxins / Oxidative Stress / Receptor-Interacting Protein Serine-Threonine Kinases / Chemical and Drug Induced Liver Injury / Liver / Acetaminophen / Antioxidants Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: J Appl Toxicol Year: 2018 Document type: Article Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thioredoxins / Oxidative Stress / Receptor-Interacting Protein Serine-Threonine Kinases / Chemical and Drug Induced Liver Injury / Liver / Acetaminophen / Antioxidants Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: J Appl Toxicol Year: 2018 Document type: Article Country of publication: Reino Unido