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Influence of obesity-related risk factors in the aetiology of glioma.
Disney-Hogg, Linden; Sud, Amit; Law, Philip J; Cornish, Alex J; Kinnersley, Ben; Ostrom, Quinn T; Labreche, Karim; Eckel-Passow, Jeanette E; Armstrong, Georgina N; Claus, Elizabeth B; Il'yasova, Dora; Schildkraut, Joellen; Barnholtz-Sloan, Jill S; Olson, Sara H; Bernstein, Jonine L; Lai, Rose K; Swerdlow, Anthony J; Simon, Matthias; Hoffmann, Per; Nöthen, Markus M; Jöckel, Karl-Heinz; Chanock, Stephen; Rajaraman, Preetha; Johansen, Christoffer; Jenkins, Robert B; Melin, Beatrice S; Wrensch, Margaret R; Sanson, Marc; Bondy, Melissa L; Houlston, Richard S.
Affiliation
  • Disney-Hogg L; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Sud A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Law PJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Cornish AJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Kinnersley B; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Ostrom QT; Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
  • Labreche K; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Eckel-Passow JE; Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MI, 55905, USA.
  • Armstrong GN; Section of Epidemiology and Population Sciences, Department of Medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
  • Claus EB; School of Public Health, Yale University, New Haven, CT, 06510, USA.
  • Il'yasova D; Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, 02115, USA.
  • Schildkraut J; Department of Epidemiology and Biostatistics, School of Public Health, Georgia State University, Atlanta, GA, 30303, USA.
  • Barnholtz-Sloan JS; Duke Cancer Institute, Duke University Medical Center, Durham, NC, 27710, USA.
  • Olson SH; Cancer Control and Prevention Program, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, 27710, USA.
  • Bernstein JL; Duke Cancer Institute, Duke University Medical Center, Durham, NC, 27710, USA.
  • Lai RK; Cancer Control and Prevention Program, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, 27710, USA.
  • Swerdlow AJ; Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MI, 55905, USA.
  • Simon M; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, 10017, USA.
  • Hoffmann P; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, 10017, USA.
  • Nöthen MM; Departments of Neurology and Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
  • Jöckel KH; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Chanock S; Division of Breast Cancer Research, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Rajaraman P; Department of Neurosurgery, University of Bonn Medical Center, Sigmund-Freud-Str. 25, Bonn, 53105, Germany.
  • Johansen C; Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, 4031, Switzerland.
  • Jenkins RB; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, 53127, Germany.
  • Melin BS; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, 53127, Germany.
  • Wrensch MR; Institute of Human Genetics, University of Bonn School of Medicine and University Hospital Bonn, Bonn, 53127, Germany.
  • Sanson M; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, 45147, Germany.
  • Bondy ML; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
  • Houlston RS; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
Br J Cancer ; 118(7): 1020-1027, 2018 04.
Article in En | MEDLINE | ID: mdl-29531326
BACKGROUND: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation. METHODS: Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship. RESULTS: No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma-glioblastoma (GBM) or non-GBM tumours. CONCLUSIONS: This study provides no evidence to implicate obesity-related factors as causes of glioma.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glioma / Obesity Type of study: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Br J Cancer Year: 2018 Document type: Article Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glioma / Obesity Type of study: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Br J Cancer Year: 2018 Document type: Article Country of publication: Reino Unido