Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation.

Zhou, Zhengyuan; Chitneni, Satish K; Devoogdt, Nick; Zalutsky, Michael R; Vaidyanathan, Ganesan

Zhou, Zhengyuan; Chitneni, Satish K; Devoogdt, Nick; Zalutsky, Michael R; Vaidyanathan, Ganesan.

Affiliation

Zhou Z; Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Chitneni SK; Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Devoogdt N; In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, (VUB), 1090 Brussels, Belgium.
Zalutsky MR; Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Vaidyanathan G; Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: ganesan.v@duke.edu.

Bioorg Med Chem ; 26(8): 1939-1949, 2018 05 01.

Article in En | MEDLINE | ID: mdl-29534937

Subject(s)
Key words

Fluorine-18; HER2; Residualizing label; Strain-promoted click reaction; VHH

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fluorine Radioisotopes / Receptor, ErbB-2 / Radiopharmaceuticals / Single-Domain Antibodies Limits: Animals / Female / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido

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