Glycerol dehydration of native and diabetic animal tissues studied by THz-TDS and NMR methods.
Biomed Opt Express
; 9(3): 1198-1215, 2018 Mar 01.
Article
in En
| MEDLINE
| ID: mdl-29541513
ABSTRACT
The optical clearing method has been widely used for different spectral ranges where it provides tissue transparency. In this work, we observed the enhanced penetration of the terahertz waves inside biological samples (skin, kidney, and cornea) treated with glycerol solutions inducing changes of optical and dielectric properties. It was supported by the observed trend of free-to-bound water ratio measured by the nuclear magnetic resonance (NMR) method. The terahertz clearing efficiency was found to be less for diabetic samples than for normal ones. Results of the numerical simulation proved that pulse deformation is due to bigger penetration depth caused by the reduction of absorption and refraction at optical clearing.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Biomed Opt Express
Year:
2018
Document type:
Article
Affiliation country:
Rusia