Predicting the Time Course of Ventricular Dilation and Thickening Using a Rapid Compartmental Model.
J Cardiovasc Transl Res
; 11(2): 109-122, 2018 04.
Article
in En
| MEDLINE
| ID: mdl-29550925
ABSTRACT
The ability to predict long-term growth and remodeling of the heart in individual patients could have important clinical implications, but the time to customize and run current models makes them impractical for routine clinical use. Therefore, we adapted a published growth relation for use in a compartmental model of the left ventricle (LV). The model was coupled to a circuit model of the circulation to simulate hemodynamic overload in dogs. We automatically tuned control and acute model parameters based on experimentally reported hemodynamic data and fit growth parameters to changes in LV dimensions from two experimental overload studies (one pressure, one volume). The fitted model successfully predicted the reported time course of LV dilation and thickening not only in independent studies of pressure and volume overload but also following myocardial infarction. Implemented in MATLAB on a desktop PC, the model required just 6 min to simulate 3 months of growth.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ventricular Function, Left
/
Hypertrophy, Left Ventricular
/
Ventricular Dysfunction, Left
/
Ventricular Remodeling
/
Patient-Specific Modeling
/
Hemodynamics
/
Models, Cardiovascular
/
Myocardial Infarction
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
J Cardiovasc Transl Res
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
Year:
2018
Document type:
Article
Affiliation country:
Estados Unidos