Metals Differentially Activate Ovarian Cancer G Protein-Coupled Receptor 1 in Various Species.
Zoolog Sci
; 35(2): 109-114, 2018 Apr.
Article
in En
| MEDLINE
| ID: mdl-29623784
ABSTRACT
Human, mouse, and zebrafish ovarian cancer G protein-coupled receptors (OGR1s) are activated by both metals and extracellular protons. In the present study, we examined whether pig, rat, chicken, and Xenopus OGR1 homologs could sense and be activated by protons and metals. We found that all homologs stimulated serum response element (SRE)-driven promoter activities when they are stimulated by protons. On the other hand, metals differentially activated the homologs. The results using chimeric receptors of human and zebrafish OGR1s indicate that the specificity of the metal-induced activation lies in the extracellular region. These results suggest that protons are an evolutionally conserved agonist of OGR1. However, the types of metals that activated the receptor differed among the homologs.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protons
/
Rats
/
Xenopus
/
Chickens
/
Sus scrofa
/
Receptors, G-Protein-Coupled
/
Metals
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Zoolog Sci
Journal subject:
BIOLOGIA
Year:
2018
Document type:
Article
Affiliation country:
Japón
Publication country:
JAPAN
/
JAPON
/
JAPÃO
/
JP