saRNAdb: Resource of Small Activating RNAs for Up-regulating the Gene Expression.
J Mol Biol
; 430(15): 2212-2218, 2018 07 20.
Article
in En
| MEDLINE
| ID: mdl-29625201
ABSTRACT
RNA activation (RNAa) is the process of enhancing selective gene expression at transcriptional level using double-stranded RNAs, targeting gene promoter. These RNA molecules are usually 21 nucleotides long and termed as small activating RNAs (saRNAs). They are involved in gene regulation, epigenetics, gain-of-function studies and have potential therapeutic applications for various diseases especially cancer. RNAa is opposite to RNA interference in functionality; however, both processes share some protein machinery. There are many RNA interference centered online resources but no one for saRNAs; therefore, we developed "saRNAdb" database (http//bioinfo.imtech.res.in/manojk/sarna/). It contains 2150 manually curated saRNA entries with detailed information about their nucleotide sequences, activities, corresponding target gene, promoter and other experimental data. Besides, saRNA-promoter binding location, predicted saRNA features, tools (off-target, map) and RNAa-related proteins with their interacting partners are provided. saRNAdb is expected to assist in RNA research especially for nucleic acid-based therapeutics development.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Up-Regulation
/
Gene Expression Regulation
/
Databases, Genetic
/
RNA, Small Untranslated
Limits:
Animals
/
Humans
Language:
En
Journal:
J Mol Biol
Year:
2018
Document type:
Article
Affiliation country:
India