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Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold.
Schwertz, Geoffrey; Witschel, Matthias C; Rottmann, Matthias; Leartsakulpanich, Ubolsree; Chitnumsub, Penchit; Jaruwat, Aritsara; Amornwatcharapong, Watcharee; Ittarat, Wanwipa; Schäfer, Anja; Aponte, Raphael A; Trapp, Nils; Chaiyen, Pimchai; Diederich, François.
Affiliation
  • Schwertz G; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
  • Witschel MC; BASF SE, Carl-Bosch-Strasse 38, 67056, Ludwigshafen, Germany.
  • Rottmann M; Swiss Tropical and Public Health Institute (SwissTPH), Socinstrasse 57, 4051, Basel, Switzerland.
  • Leartsakulpanich U; Universität Basel, Petersplatz 1, 4003, Basel, Switzerland.
  • Chitnumsub P; National Center for Genetic Engineering and Biotechnology, 113 Thailand Science Park, Phahonyothin Road, Pathumthani, 12120, Thailand.
  • Jaruwat A; National Center for Genetic Engineering and Biotechnology, 113 Thailand Science Park, Phahonyothin Road, Pathumthani, 12120, Thailand.
  • Amornwatcharapong W; National Center for Genetic Engineering and Biotechnology, 113 Thailand Science Park, Phahonyothin Road, Pathumthani, 12120, Thailand.
  • Ittarat W; Department of Biochemistry and Center for Excellence in Protein and Enzyme Technology, Faculty of Science, Mahidol University, 272 Rama VI Road, Bangkok, 10400, Thailand.
  • Schäfer A; National Center for Genetic Engineering and Biotechnology, 113 Thailand Science Park, Phahonyothin Road, Pathumthani, 12120, Thailand.
  • Aponte RA; Swiss Tropical and Public Health Institute (SwissTPH), Socinstrasse 57, 4051, Basel, Switzerland.
  • Trapp N; Universität Basel, Petersplatz 1, 4003, Basel, Switzerland.
  • Chaiyen P; BASF SE, Carl-Bosch-Strasse 38, 67056, Ludwigshafen, Germany.
  • Diederich F; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
ChemMedChem ; 13(9): 931-943, 2018 05 08.
Article in En | MEDLINE | ID: mdl-29655285
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium / Glycine Hydroxymethyltransferase / Spiro Compounds / Enzyme Inhibitors / Oxindoles / Indenes Limits: Humans Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2018 Document type: Article Affiliation country: Suiza
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium / Glycine Hydroxymethyltransferase / Spiro Compounds / Enzyme Inhibitors / Oxindoles / Indenes Limits: Humans Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2018 Document type: Article Affiliation country: Suiza