Radiotherapy and checkpoint inhibitors: a winning new combination?
Ther Adv Med Oncol
; 10: 1758835918768240, 2018.
Article
in En
| MEDLINE
| ID: mdl-29662550
ABSTRACT
Immune checkpoint blockade has recently emerged as an important therapeutic approach to the management of malignancies across multiple disease settings. Concomitantly, there has been an increasing appreciation for the role of radiotherapy in eliciting and promoting tumor-directed immune responses. In this review, we discuss the clinical evidence to date on combinations of radiotherapy with immune checkpoint inhibitors, both from the standpoint of safety and efficacy. We highlight important but yet-unanswered questions for this combination approach, as well as their implications for future prospective studies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Observational_studies
Language:
En
Journal:
Ther Adv Med Oncol
Year:
2018
Document type:
Article
Affiliation country:
Estados Unidos