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A novel SMAC mimetic APG-1387 exhibits dual antitumor effect on HBV-positive hepatocellular carcinoma with high expression of cIAP2 by inducing apoptosis and enhancing innate anti-tumor immunity.
Pan, Wentao; Luo, Qiuyun; Yan, Xianglei; Yuan, Luping; Yi, Hanjie; Zhang, Lin; Li, Baoxia; Zhang, Yuxin; Sun, Jian; Qiu, Miao-Zhen; Yang, Da-Jun.
Affiliation
  • Pan W; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 51000, PR China; Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China.
  • Luo Q; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 51000, PR China; Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China.
  • Yan X; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 51000, PR China; Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China.
  • Yuan L; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 51000, PR China; Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China.
  • Yi H; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 51000, PR China; Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China.
  • Zhang L; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 51000, PR China; Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China.
  • Li B; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 51000, PR China; Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China.
  • Zhang Y; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 51000, PR China; Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China.
  • Sun J; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 51000, PR China; Department of Clinical Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China. Electronic address: sunjian@sysucc.org.cn.
  • Qiu MZ; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 51000, PR China; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China. Electronic address: qiumzh@sysucc.org.cn.
  • Yang DJ; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 51000, PR China; Suzhou Ascentage Pharma Inc., Jiangsu 215123, PR China. Electronic address: yangdj@sysucc.org.cn.
Biochem Pharmacol ; 154: 127-135, 2018 08.
Article in En | MEDLINE | ID: mdl-29679556
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Azepines / Hepatitis B virus / Carcinoma, Hepatocellular / Mitochondrial Proteins / Intracellular Signaling Peptides and Proteins / Baculoviral IAP Repeat-Containing 3 Protein / Liver Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochem Pharmacol Year: 2018 Document type: Article Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Azepines / Hepatitis B virus / Carcinoma, Hepatocellular / Mitochondrial Proteins / Intracellular Signaling Peptides and Proteins / Baculoviral IAP Repeat-Containing 3 Protein / Liver Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochem Pharmacol Year: 2018 Document type: Article Country of publication: Reino Unido