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Impact of Metabolic Diseases on Cerebral Circulation: Structural and Functional Consequences.
Coucha, Maha; Abdelsaid, Mohammed; Ward, Rebecca; Abdul, Yasir; Ergul, Adviye.
Affiliation
  • Coucha M; South University, School of Pharmacy, Savannah, Georgia, USA.
  • Abdelsaid M; Mercer University, School of Medicine, Savannah, Georgia, USA.
  • Ward R; Department of Neuroscience & Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
  • Abdul Y; Charlie Norwood VA Medical Center, Augusta, Georgia, USA.
  • Ergul A; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Compr Physiol ; 8(2): 773-799, 2018 03 25.
Article in En | MEDLINE | ID: mdl-29687902
ABSTRACT
Metabolic diseases including obesity, insulin resistance, and diabetes have profound effects on cerebral circulation. These diseases not only affect the architecture of cerebral blood arteries causing adverse remodeling, pathological neovascularization, and vasoregression but also alter the physiology of blood vessels resulting in compromised myogenic reactivity, neurovascular uncoupling, and endothelial dysfunction. Coupled with the disruption of blood brain barrier (BBB) integrity, changes in blood flow and microbleeds into the brain rapidly occur. This overview is organized into sections describing cerebrovascular architecture, physiology, and BBB in these diseases. In each section, we review these properties starting with larger arteries moving into smaller vessels. Where information is available, we review in the order of obesity, insulin resistance, and diabetes. We also tried to include information on biological variables such as the sex of the animal models noted since most of the information summarized was obtained using male animals. © 2018 American Physiological Society. Compr Physiol 8773-799, 2018.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cerebrovascular Circulation / Metabolic Diseases Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Compr Physiol Year: 2018 Document type: Article Affiliation country: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cerebrovascular Circulation / Metabolic Diseases Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Compr Physiol Year: 2018 Document type: Article Affiliation country: Estados Unidos