Commercial Products for Osteochondral Tissue Repair and Regeneration.
Adv Exp Med Biol
; 1058: 415-428, 2018.
Article
in En
| MEDLINE
| ID: mdl-29691833
ABSTRACT
The osteochondral tissue represents a complex structure composed of four interconnected structures, namely hyaline cartilage, a thin layer of calcified cartilage, subchondral bone, and cancellous bone. Due to the several difficulties associated with its repair and regeneration, researchers have developed several studies aiming to restore the native tissue, some of which had led to tissue-engineered commercial products. In this sense, this chapter discusses the good manufacturing practices, regulatory medical conditions and challenges on clinical translations that should be fulfilled regarding the safety and efficacy of the new commercialized products. Furthermore, we review the current osteochondral products that are currently being marketed and applied in the clinical setting, emphasizing the advantages and difficulties of each one.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bone and Bones
/
Bone Regeneration
/
Bone Substitutes
/
Tissue Engineering
/
Regenerative Medicine
/
Hyaline Cartilage
Limits:
Animals
/
Humans
Language:
En
Journal:
Adv Exp Med Biol
Year:
2018
Document type:
Article
Affiliation country:
Portugal