Inhibition of Chlamydia trachomatis Growth During the Last Decade: A Mini-Review.
Mini Rev Med Chem
; 18(16): 1363-1372, 2018.
Article
in En
| MEDLINE
| ID: mdl-29692244
ABSTRACT
Chlamydia trachomatis is responsible for the most frequent sexually transmitted bacterial infection in the world and for trachoma, the world's leading infectious cause of blindness. Genital chlamydial infection is very common among sexually active young people, and when untreated, leads to serious complications. No vaccine is yet available for this bacterial infection. Although Chlamydia resistance to antibiotics is rarely observed in vivo, studies showed that 10-20% of patients remain infected at the end of antibiotherapy, without being reinfected. The present review gives a global and comprehensive overview of the different targets and the related inhibitors proposed during the last decade, with a view to limiting the growth of this human pathogen. Metallic and polymeric nanoparticles in this field are also briefly presented.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chlamydia Infections
/
Sexually Transmitted Diseases
/
Chlamydia trachomatis
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Mini Rev Med Chem
Journal subject:
QUIMICA
Year:
2018
Document type:
Article
Affiliation country:
Francia
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS