Interregional synaptic maps among engram cells underlie memory formation.
Science
; 360(6387): 430-435, 2018 04 27.
Article
in En
| MEDLINE
| ID: mdl-29700265
ABSTRACT
Memory resides in engram cells distributed across the brain. However, the site-specific substrate within these engram cells remains theoretical, even though it is generally accepted that synaptic plasticity encodes memories. We developed the dual-eGRASP (green fluorescent protein reconstitution across synaptic partners) technique to examine synapses between engram cells to identify the specific neuronal site for memory storage. We found an increased number and size of spines on CA1 engram cells receiving input from CA3 engram cells. In contextual fear conditioning, this enhanced connectivity between engram cells encoded memory strength. CA3 engram to CA1 engram projections strongly occluded long-term potentiation. These results indicate that enhanced structural and functional connectivity between engram cells across two directly connected brain regions forms the synaptic correlate for memory formation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Synapses
/
CA1 Region, Hippocampal
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CA3 Region, Hippocampal
/
Memory
/
Neurons
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Science
Year:
2018
Document type:
Article
Affiliation country:
Corea del Sur