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HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation.
Kijima, Toshiki; Prince, Thomas L; Tigue, Megan L; Yim, Kendrick H; Schwartz, Harvey; Beebe, Kristin; Lee, Sunmin; Budzynski, Marek A; Williams, Heinric; Trepel, Jane B; Sistonen, Lea; Calderwood, Stuart; Neckers, Len.
Affiliation
  • Kijima T; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States.
  • Prince TL; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States. tprince@geisinger.edu.
  • Tigue ML; Urology Department, Geisinger Clinic, WCR 221, Danville, PA, 17821, United States. tprince@geisinger.edu.
  • Yim KH; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States.
  • Schwartz H; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States.
  • Beebe K; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States.
  • Lee S; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States.
  • Budzynski MA; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States.
  • Williams H; Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, BioCity, Tykistökatu 6, Turku, FIN-20520, Finland.
  • Trepel JB; Urology Department, Geisinger Clinic, WCR 221, Danville, PA, 17821, United States.
  • Sistonen L; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States.
  • Calderwood S; Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, BioCity, Tykistökatu 6, Turku, FIN-20520, Finland.
  • Neckers L; Radiation Oncology, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA, 02215, United States.
Sci Rep ; 8(1): 6976, 2018 05 03.
Article in En | MEDLINE | ID: mdl-29725069
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / HSP90 Heat-Shock Proteins / Heat Shock Transcription Factors Type of study: Prognostic_studies Limits: Humans Language: En Journal: Sci Rep Year: 2018 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / HSP90 Heat-Shock Proteins / Heat Shock Transcription Factors Type of study: Prognostic_studies Limits: Humans Language: En Journal: Sci Rep Year: 2018 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido