Pancreatic stiffness response to an oral glucose load in obese adults measured by magnetic resonance elastography.
Magn Reson Imaging
; 51: 113-119, 2018 09.
Article
in En
| MEDLINE
| ID: mdl-29729951
ABSTRACT
BACKGROUND:
To test the feasibility of magnetic resonance elastography (MRE) for assessing changes in pancreatic stiffness of obese adults administered an oral glucose load.METHODS:
MRE scans were performed on 21 asymptomatic obese volunteers (BMIâ¯≥â¯27â¯kg/m2) before and after receiving a 75-g oral glucose load, and repeated in 7â¯days without a glucose load. Shear waves at 40 and 60â¯Hz were introduced into the upper abdomen by a pneumatic drum driver (diameter of 12â¯cm). Two radiologists subjectively graded the overall quality of the wave images of the pancreas using a scale from 1 to 4, in which suboptimal image quality was considered to be scores of 1 and 2.RESULTS:
Good inter-observer agreement was found for image quality at both frequencies (kappaâ¯=â¯0.805 for 40â¯Hz and 0.762 for 60â¯Hz). The median overall image quality score was significantly higher in 40â¯Hz than that of 60â¯Hz (4 versus 2). At 40â¯Hz, pancreatic stiffness in response to oral glucose had a decrease of 6.7% (pre vs post 1.17⯱â¯0.13â¯kPa vs 1.08⯱â¯0.12â¯kPa; Pâ¯<â¯0.001), whereas the change in stiffness was not significant at 60â¯Hz (pre vs post 2.01⯱â¯0.21â¯kPa vs 2.02⯱â¯0.24â¯kPa; Pâ¯=â¯0.695). Excellent intersession agreement was found for MRE acquisitions at 40â¯Hz with an overall intraclass correlation coefficientâ¯=â¯0.947 (95% confidence interval 0.913-0.967).CONCLUSION:
MRE at 40â¯Hz provides good-quality wave images and high sensitivity to changes in the mechanical properties of pancreatic tissue in obese volunteers after an oral glucose load.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancreas
/
Elasticity Imaging Techniques
/
Glucose
/
Obesity
Type of study:
Diagnostic_studies
/
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Magn Reson Imaging
Year:
2018
Document type:
Article
Affiliation country:
China