Radiotherapy is essential after complete response to asparaginase-containing chemotherapy in early-stage extranodal nasal-type NK/T-cell lymphoma: A multicenter study from the China Lymphoma Collaborative Group (CLCG).
Radiother Oncol
; 129(1): 3-9, 2018 10.
Article
in En
| MEDLINE
| ID: mdl-29739712
ABSTRACT
PURPOSE:
This study aimed to clarify the benefit of radiotherapy (RT) in patients with early-stage extranodal NK/T-cell lymphoma (NKTCL) who achieve a complete response (CR) after asparaginase-containing chemotherapy (CT). PATIENTS ANDMETHODS:
Of 240 patients achieved a CR after asparaginase-containing CT, 202 patients received additional RT (CTâ¯+â¯RT), and 38 patients did not (CT alone).RESULTS:
Compared to CT alone, CTâ¯+â¯RT significantly improved overall survival (OS), disease-free survival (DFS) and locoregional control (LRC). The 5-year OS, DFS and LRC rates were 84.9%, 76.2% and 84.9% for CTâ¯+â¯RT, compared to 58.9% (Pâ¯=â¯0.006), 43.6% (Pâ¯=â¯0.001) and 62.1% (Pâ¯=â¯0.026) for CT alone. The 5-year cumulative disease recurrence rate was 18.8% for CTâ¯+â¯RT compared to 46.9% (Pâ¯=â¯0.003) for CT alone. High-dose RT (≥50â¯Gy) significantly decreased the risk of locoregional recurrence. The 5-year cumulative locoregional failure rate was 35.5% for patients receiving <50â¯Gy compared to 8.8% for patients receiving ≥50â¯Gy (Pâ¯=â¯0.028).CONCLUSIONS:
For patients with early-stage NKTCL who achieve a CR after asparaginase-containing CT, omission of RT results in frequent locoregional recurrence and a poor prognosis; RT is essential to improve locoregional control and survival.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antineoplastic Combined Chemotherapy Protocols
/
Lymphoma, Extranodal NK-T-Cell
Type of study:
Clinical_trials
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Radiother Oncol
Year:
2018
Document type:
Article