A Phase I, Single-Ascending-Dose Study in Healthy Subjects to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DS-2969b, a Novel GyrB Inhibitor.

Dennie, Justin; Vandell, Alexander G; Inoue, Satoshi; Gajee, Roohi; Pav, Joseph; Zhang, George; Zamora, Cynthia; Masuda, Nobuhisa; Uchiyama, Minoru; Yamada, Makiko; Senaldi, Giorgio

Dennie, Justin; Vandell, Alexander G; Inoue, Satoshi; Gajee, Roohi; Pav, Joseph; Zhang, George; Zamora, Cynthia; Masuda, Nobuhisa; Uchiyama, Minoru; Yamada, Makiko; Senaldi, Giorgio.

Affiliation

Dennie J; Daiichi Sankyo Pharma Development, Basking Ridge, NJ, USA.
Vandell AG; Daiichi Sankyo Pharma Development, Basking Ridge, NJ, USA.
Inoue S; Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Gajee R; Daiichi Sankyo Pharma Development, Basking Ridge, NJ, USA.
Pav J; Daiichi Sankyo Pharma Development, Basking Ridge, NJ, USA.
Zhang G; Daiichi Sankyo Pharma Development, Basking Ridge, NJ, USA.
Zamora C; Worldwide Clinical Trials, San Antonio, TX, USA.
Masuda N; Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Uchiyama M; Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Yamada M; Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Senaldi G; Daiichi Sankyo Pharma Development, Basking Ridge, NJ, USA.

J Clin Pharmacol ; 58(12): 1557-1565, 2018 12.

Article in En | MEDLINE | ID: mdl-29746725

Subject(s)
Key words

Clostridium difficile; Clostridium difficile infection; DS-2969b; antibiotic; antimicrobial agents

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Thiadiazoles / Topoisomerase II Inhibitors / Imidazoles Type of study: Clinical_trials / Prognostic_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: J Clin Pharmacol Year: 2018 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido

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